Margaret Lee has organized and exhibited work at numerous venues domestically and internationally including Misako & Rosen Gallery, Tokyo, Japan, The Windows, Barneys, New York, Concentrations HK: Margaret Lee, curated by Gabriel Ritter, Duddell’s x DMA, Hong Kong, China, Made in L.A, 2014 Hammer Museum Biennial, Los Angeles, 2013 Biennale de Lyon, de, da do…da, Carpenter Center for the Visual Arts, Harvard University, Cambridge, MA, Caza, curated by Sofía Hernández Chong Cuy, Bronx Museum, New York, NO MAN’S LAND: Women Artists from the Rubell Family Collection, Rubell Family Collection, Miami, New Pictures of Common Objects, curated by Christopher Lew, MoMA PS1, New York, and Looking Back, White Columns, New York, amongst others.

In 2009, Lee founded the artist-run space 179 Canal and is the Co-founder of the gallery 47 Canal. Public collections with works by the artist include: The Solomon R. Guggenheim Museum, Dallas Museum of Art, Dikeou Collection, Rubell Family Collection, and the Astrup Fearnley Museet.